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Enzymatically synthesized oxylipin, the jasmonic acid (JA) and a precursor molecule 12-oxo-phytodienoic acid (OPDA) were shown to accumulate in response to pathogen infection [98]

18,19 The multifactorial nature of GI diseases, including altered motility, microbial dysbiosis, and visceral hypersensitivity, makes single-target therapies insufficient

In these conditions, the gut lining is compromised, allowing endotoxins and other antigens to leak into the bloodstream and trigger an immune response