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GLP-1RA Lipid-Specific Outcomes While the GLP-1RAs used for weight loss, semaglutide and tirzepatide, have garnered much focus, multiple other GLP-1RA medications have shown positive outcomes on lipid profiles: dulaglutide has shown reduction in total cholesterol and LDL-C [65], liraglutide has shown reduction in LDL-C and ApoCIII [66], and exenatide has shown reduction in LDL-C and total cholesterol and increase in HDL-C [67]

However, some studies have reported that rosiglitazone and pioglitazone, both TZD drugs, could be associated with an increased risk of prostate and pancreatic cancer [107]

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licensed healthcare providers independently evaluate eligibility and decide whether any prescription is medically appropriate