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A third possibility involves cytosolic degradation of GS-conjugates although evidence for appreciable accumulation of these compounds in this compartment is lacking

When GSSG accumulates excessively due to dysfunctional SLC33A1 activity, this inhibits enzymes required for proper disulfide bond formation and quality control, resulting in protein misfolding and aggregation within the ER

Research analyzing thousands of patients has linked such use to complications like gastroparesis (delayed stomach emptying), bowel obstruction, and pancreatitis