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A study in the New England Journal of Medicine found that among adults who were overweight or obese, those who injected semaglutide weekly lost nearly 15% of their body weight after 68 weeks

And that's why the manufacturer really encourages low titration at a lower dose to avoid these side effects

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127 Thus, the Duchenne muscular dystrophy is a primary genetic astrocytopathy that impairs synaptic transmission, causes excitotoxicity and secondary neurodegeneration