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Quick answer: In head-to-head trials, tirzepatide (a dual GLP-1/GIP receptor agonist) produced greater weight loss than semaglutide (a single GLP-1 agonist) 20.2% vs 13.7% over 72 weeks in SURMOUNT-5 though semaglutides single-pathway selectivity keeps it valuable in research

Semaglutide for obesity: Clinical effectiveness and safety

Studies of semaglutide in rats, rabbits, and monkeys found the animals experienced higher rates of miscarriage, and that their babies more often did not grow to full size

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