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It significantly upregulates VEGF (vascular endothelial growth factor) expression, stimulating endothelial cell proliferation and tubule formation

The differential diagnosis of malignant peripheral nerve sheath tumor from melanoma can also be very challenging, especially as these melanoma variants, particularly desmoplastic/spindle cell melanomas, show no or very little expression of melanocytic markers such as MelanA and HMB45

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Distribution and habitat [edit] The Gila monster is found in the Southwestern United States and Mexico, across a range including Sonora, Arizona, and parts of California, Nevada, Utah, and New Mexico