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In contrast, heat shock protein 90 can induce ferroptosis by phosphorylating receptor-interacting protein 1 (RIP1), a key regulator of necroptosis, and inhibiting GPX4 (98)

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Maintaining healthy L-carnitine levels is essential for skeletal and cardiac muscle function and, importantly, for maintaining mitochondrial health, which is important for healthy aging [7274].* In preclinical studies, it has been shown that L-carnitine insufficiency is associated with aging and compromised mitochondrial function and metabolic health [75].* L-carnitine and ALCAR supplementation may help to maintain healthy L-carnitine levels in tissues, support mitochondrial performance, and promote healthy aging [76,77]