how were glp 1 agonists discovered PDB-101: Molecule of the Month: GLP-1 Receptor GLP-1 receptor agonists show promise

In summary, incretins serve as integral contributors to glucose metabolism by promoting insulin release, inhibiting glucagon secretion, supporting beta cell function and survival, and mitigating appetite and food consumption

Samir H, Mandour AS, Radwan F, Swelum AA, Yoshida T, Tanaka R, Nagaoka K, Watanabe G

Some preproglucagon-expressing neurons in the nucleus tractus solitarius of the brain stem have also been shown to synthesise GLP-1 (2)

Many researchers feel that this is why most obese people exhibit leptin resistance they have a decreased response to leptin and therefore exhibit increased appetite and reduced energy expenditure