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Our objective was to investigate whether Cerebrolysin stabilizes the BBB in a way that can be monitored by measuring the serum levels of key tight junction (TJ) proteins, specifically occludin (OCL), claudin-5 (CLDN-5), and zonula occludens-1 (ZO-1) Methods: CER ebrolysin effect on B lood-brain barrier/ E ndothelium integrity during R eperfusion therapy of ac U te ischemic S troke (CERBERUS Study) registered in Clinical Trials (Approval Number: 392/23) is single-center, prospective, randomized study

The program includes testing for CBD and THC to verify label claims and protect against positive drug tests

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Preclinical safety evaluation across rodents, dogs, and rabbits found no test-related adverse effects across a wide exposure range