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While functional neuroimaging changes have been reported in some studies, no direct changes in the established biomarkers of AD have been observed

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Improvement may become more noticeable after achieving significant weight loss, which may require several months of treatment

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On November 8, 2023 , the FDA approved medications containing tirzepatide under the brand names Mounjaro and Zepbound for type 2 diabetes and weight management in qualifying adults

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