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In CKD, a clinical trial based on the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) showed that, compared to the placebo group, both 150 mg and 300 mg doses of canakinumab significantly reduced eGFR and creatinine levels in CKD patients and decreased the incidence of major adverse cardiovascular events in high-risk atherosclerotic patients with CKD, particularly among those with a strong anti-inflammatory response to initial treatment [326]

Sources & references 1 SURMOUNT () (22.5% ) 2 (5-7% ) 3Retatrutide Phase 2 NEJM 2023 Jastreboff et al

Masheb & White, 2012), and a subset of these patients report significant weight loss and symptoms of starvation (Bodell & Keel, 2015)

For alcohol and cancer, risk increases with each additional unit of consumption