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A series of placebo-controlled, randomized, double-blind clinical trials investigating intravenous or intranasal administration of GSH showed improvements in motor symptoms, but these improvements lacked statistical significance compared to placebo (203205)

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Therefore, we speculated that the enhanced oxidative stress induced by fullerenols may be related to the reduction in ER expression caused by decreased E3 levels

however, further high-quality clinical trials are needed to standardize dosage, strain selection, and safety evaluations, facilitating the translational application of these therapies