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Agent-level network meta-analysis Major adverse cardiovascular events In the agent-level NMA, tirzepatide significantly reduced the risk of MACE compared with placebo (HR 0.81, 95% CI 0.700.94) and with lixisenatide (HR 0.79, 95% CI 0.650.97)

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Certainly, the therapeutic reach of GLP-1s is already expanding , with recent approvals for reduction of cardiovascular events and sleep apnea , and several companies exploring their potential to treat chronic kidney disease, Alzheimers, Parkinsons disease and more.

CrossRef GLP-1/GIP agonists and cancer: mechanisms, evidence, and nutrition implications Sedat Arslan, Ayca Aydin Academia Oncology.2026;[Epub] CrossRef From diabetes to tumor growth: unravelling the impact of glucose-lowering therapies R