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Consistent with the restoration of lipid catabolic gene expression, GSEA demonstrated significant enrichment of fatty acid metabolism (NES = 1.575, P = 0.0061) and fatty acid degradation pathways (NES = 1.729, P = 0.0020) in the HFD + Ret group compared with the HFD group

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This multi-target approach has positioned Retatrutide as an important compound in contemporary metabolic science