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Targeting CYP17: established and novel approaches in prostate cancer

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A key advancement was the development of MZ-3-149, an analog that contained aspartic acid at position 28

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289 Cigarette smoke contains thousands of chemicals, many of which have known toxicity

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Both share the same core GHRH(1-29) modified sequence with Aib substitutions at positions 2, 8, 15, and 27

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