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For instance, PT-141 may mitigate oxidative damage to vascular endothelial cells and inhibit atherosclerosis formation by promoting the expression and activity of antioxidant enzymes

GSH plays a pivotal role in maintaining redox balance, regulating immune responses, and supporting energy production and cellular repair (Figure 3) [29]

[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Campbell JE, Drucker DJ

As compared to the wild-type -Thalassemia/HbE patients, the heterozygous UGT1A6*2 without UGT1A1*28 genotype exhibited a reduction in AUC of the free drug and of APAP glucuronide which might be due to UGT1A6*2 polymorphism