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Therefore, mechanistic evaluation of nano-phytomedicines should differentiate between attenuation of oxidative damage and modulation of redox-dependent signaling cascades, particularly those governing neuronal survival and mitochondrial homeostasis

KD lowers insulin, causing a decrease in IGF-1, which consequently leads to an increase in IGFBP-3 (191)

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2 Fe (1) 3+ + ascorbate 2 Fe 2+ + dehydroascorbate 2 Fe (2) 2+ + 2 H 2 O 2 2 Fe 3+ + 2OH + 2 OH Vitamin C is a reducing agent and antioxidant, and reacts with reactive oxygen species, such as the hydroxyl radical