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In specific embodiments, auris formulations described herein are formulated to provide a delivered perilymph-suitable osmolarity at the target site of action of about 250 to about 320 mOsm/L and preferably about 270 to about 320 mOsm/L

Saline (0.9% sodium chloride) is another option sometimes mentioned, but it can occasionally cause peptide aggregation or affect solubility, depending on the specific amino acid sequence

*Correspondence: Cesare Indiveri, [email protected] This article was submitted to Mitochondrial Research, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers