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10.3389/fphar.2019.00404 438 TouchefeuY.MontassierE.NiemanK.GastinneT.PotelG.Bruley des VarannesS.et al

What you're experiencing might be purging, a temporary phenomenon where skin looks worse before it looks dramatically better

61 This unique cell death pattern, triggered by iron-dependent peroxidation of phospholipids, is governed by many cellular metabolic pathways, including the redox balance, mitochondrial function, amino acids metabolism, blood lipids, and glucose metabolism