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Renal Impairment: Initiation of metformin is generally not recommended when eGFR is below 45 mL/min

usually resolves within 12 weeks per dose Diarrhoea particularly during the first 46 weeks Constipation often develops in weeks 412 as gastric emptying slows Abdominal discomfort and bloating Reduced appetite this is the therapeutic effect, but can feel intense at first Fatigue often related to reduced caloric intake rather than the drug itself Discontinuation rates in ATTAIN-1 were higher with orforglipron than placebo typically due to persistent GI symptoms during dose escalation

If the patient doesnt change what theyre doing, theyll have a hard time no matter what we prescribe. As a relatively new class of drugs, there isnt much long-term data on adherence when it comes to semaglutides

Some, like muscles, are bustling cities with a sprawling network of highways (blood vessels) delivering oxygen and nutrients for repair