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Dysfunction of the systemic or local dopaminergic system during inflammation has been found in animal models and patients with various inflammatory diseases, such as Parkinson disease, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis, indicating an important role that DRs play in inflammatory diseases

(C) Relative gene expression of selected phase 2 enzymes exposed to 10 uM SFN for 48 h

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