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It has been found that cancer cells can activate FSP1-mediated ferroptosis resistance in surrounding tumor cells by secreting miRNAs through exosomes

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FIGURE 2 The intrinsic pathway (mitochondrial pathway) involves two primary mechanisms of apoptosis: cytochrome c (Cyt C) release and the opening of the mitochondrial permeability transition pore (MPTP) (Kulikov et al., 2012