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According to the World Health Organization, in 2019, diabetes was the cause of 1.5 million deaths

To apply this methodology to the anti-Met macrocycles, we designed precursor macrocycles bearing a short peptide motif containing a Cys residue at the C terminus and modified the sulfhydryl group with three bis-maleimide cross-linkers with different lengths, C6, PEG3 and PEG11 (Supplementary Table 2)

RAW264.7 cells were fixed with 4% paraformaldehyde, permeabilized with ice-cold methanol, and blocked with MinuteBlock Blocking Buffer (Affinibody, China)