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Semeraro F, Ammollo CT, Morrissey JH, Dale GL, Friese P, Esmon NL, et al

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These osteocartilaginous outgrowths form at the joint margins at the interface of the synovium, periosteum, and articular cartilage, yet their development is tightly linked to the mechanical and molecular alterations occurring in the subchondral region (Li et al., 2013)

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