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doi: 10.1016/j.ejphar.2019.01.030

Abstract This study aimed to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the solubility, oral bioavailability, and hypolipidemic effects of syringic acid (SA), a bioactive and poorly-soluble polyphenol

ALT change at week 24 averaged -2.2 IU/L, -13.3 IU/L, -13.7 IU/L, and -15.2 IU/L in the placebo, 1.2-mg, 1.8-mg, and 2.4-mg arms

Interestingly, loss of GPx-4 promotes apoptotic signaling by allowing for the accumulation of oxidized membrane phospholipids, thereby stimulating AIF transmigration from mitochondria to the nucleus to initiate apoptotic signaling (320)