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Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke

Wang S, Wei W, Ma N, Qu Y, Liu Q

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Notably, five overexpressed GST isozymes reduced the typical accumulation of ROS, which suggested that these isozymes could glutathionylate ROS-generating enzymes with GSH, thus inhibiting superoxide and hydrogen peroxide in both mitochondria and the cytoplasm [50]