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Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

ImPACT has become the world-wide standard tool to assess sports-related concussions, and has been used in over 23 million athletes (as of 2022)

The mechanisms include vascular disease, hormonal imbalances (particularly reduced testosterone in men), psychological factors, and reduced physical stamina