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The general clinical principle is that obesity is a chronic disease, and like blood pressure or diabetes medications, weight loss medications often need to continue long-term to maintain results

doi: 10.1016/j.bpc.2010.06.003 143 PietzschJHoppmannS

Findings from this study showed that chronic intracerebroventricular (ICV) of leptin, with no spill over in the circulation, improved cardiac function after ischemia/reperfusion injury in male and female rats and that this effect is not transmitted from the brain to the heart by cardiac sympathetic nerves

Schisantherin A induces cell apoptosis through ROS/JNK signaling pathway in human gastric cancer cells