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Natural GLP-1 has a half-life of about 2 mins and is degraded primarily through the action of dipeptidyl peptidase-4 (DPP-IV)

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This approach was chosen to streamline the extensive data processing required for hundreds of sample injections, as the well-defined, predictable in vitro cell culture matrix, combined with precise retention time matching, provided sufficient confidence for analyte identification

The concern is that temperature cycling promotes condensation and aggregation, reducing stability more than consistent storage at either temperature