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Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci

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Important : If B12 deficiency is suspected, folic acid should not be started before B12 deficiency is excluded or treated, as this can worsen neurological complications

Surgery should be deferred when shedding remains active, weight or nutrition is unstable, the diagnosis is uncertain, inflammatory or scarring disease is active, donor miniaturization is diffuse, expectations are unrealistic, or the patient believes transplantation will stop future shedding