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J Appl Genet

Colpo GD, Venna VR, McCullough LD, Teixeira AL

Biological plausibility arguments cut both ways: KLOW's mechanisms don't suggest catastrophic toxicity, but they do suggest pathways for subtle, delayed effects that would only surface in long-duration cohorts

The observation of SHMT2 upregulation in response to RT also applies to multiple myeloma models, underscoring a broader application of sertraline treatment across cancers (Supplementary Fig