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A separate set of enzymes and transporters also plays a buffering role by eliminating acetyl-CoA from inside mitochondria created by the pyruvate dehydrogenase complex that is in excess of its utilization by the Krebs cycle

Jun 2022;36(6):2342-2351

Multivariate analysis revealed that patients with liver cirrhosis had more than twice the risk of developing depression (odds ratio = 2.172), concluding that cirrhosis was an independent risk factor for developing major depressive disorder (45)