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This was confirmed by giving the volunteers antibiotics for one week to suppress the gut bacteria, then repeating the L-carnitine supplement experiment

[1] [3] Humans synthesize carnitine from the substrate TML (6- N -trimethyllysine), which is in turn derived from the methylation of the amino acid lysine

The pattern is consistent: patients with baseline nutrient deficiencies (common in calorie-restricted diets) show measurably better fat loss velocity when lipotropic support is added, while patients with adequate baseline status see minimal additional benefit