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Epilepsy occurs in 55% of patients with the homozygous c.98-104del7ins3 mutation in the BTD gene, and for 38% of these patients, epilepsy is the initial symptom [73]

These drugs are the first choice for doctors and patients for treating diseases such as diabetes and obesity

Although the GH-releasing effect was extremely weak and could only be observed in vitro , it specifically promoted GH release without affecting the secretion of other anterior pituitary hormones, including luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone, and prolactin

It is important to note that this mechanism, while biologically plausible, is not yet validated by large-scale controlled trials, and individual results vary considerably depending on baseline melanin levels, skin type, and dosage