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VPA-induced mitochondrial dysfunction is associated with lower consumption of oxygen and levels of ATP (adenosine triphosphate), as well as lower DNA polymerase gamma expression, which is participating in mtDNA (mitochondrial DNA) replication and repair (Li et al., 2015), reduced potential of mitochondrial membrane of the liver, respiratory control ratios, and enhanced swelling of mitochondria because of calcium flux alterations (Komulainen et al., 2015)

GLP-1 drugs for weight loss typically involve higher dosages than the same drug taken to manage diabetes

doi: 10.1016/s0140-6736(11)61452-9 6 DarrasVMVan HerckSL

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