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Mitochondrial ROS are mainly produced through the electron transport chain (ETC) during oxidative phosphorylation (33)
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Clearance of a drug by the liver is determined by hepatic blood flow (Q H ) and the intrinsic ability of the liver to extract the drug (extraction ratio, or ER H ) : Drugs with a high extraction ratio (approaching 1) have Cl H equal to the hepatic blood flow
Although less prominently, glucagon-like peptide-1 receptor agonists (GLP-1RA) can also attenuate renal dysfunction in type 2 diabetes
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