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If you experience severe pain in your stomach area that will not go away, with or without vomiting, while taking a GLP-1 agonist, stop taking your medication and call your healthcare provider right away

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Science 293 , 24042405 (2001)

Patients achieving a 5% reduction from baseline in body weight was a co-primary outcome in the STEP 1 to STEP 3 studies, and there were greater percentages of patients in the semaglutide group than in the placebo group who achieved a 5% weight loss by week 68 in each of STEP 1 (odds ratio [OR] = 11.22 [95% CI, 8.88 to 14.19