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The ability to enhance therapeutic efficacy while minimizing drug dosage and adverse effects makes this strategy particularly promising for further exploration in clinical settings

The metabolic impacts of GLP-1RAs go beyond their conventional functions, as they operate through a variety of interconnected systems linking the gastrointestinal (GI) tract, central nervous system (CNS), and immune system [5-7]

Its low molecular weight (~340 Da) means it reaches tissue compartments that larger peptides may not, and its stability profile is well-suited to combination formulations

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