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Consistent with the effects in rat PSCs, high glucose and TGF1 levels enhanced the proliferation and decreased the apoptosis of PSCs in the LG group, whereas GSH and SB431542 prevented the effects induced by high glucose

The combined effect of the catechol and aldehyde components in DOPAL increases its reactivity, leading to the modification of functional protein residues, protein aggregation, oxidative stress, and cell death