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Some of the most interesting targets in potential weight-loss drugs are analogs of hormones that act in hunger- and satiety-related metabolic pathways, says Indiana University Bloomington chemist Richard DiMarchi, a former Lilly researcher who sold his diabetes start-ups to Novo Nordisk

Free radicals produced by oxidative stress affect the structure and function of neural cells, which may disrupt antioxidant mechanisms and ultimately lead to neurodegeneration

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Winfrey has lost her latest weight using a weight-loss drug and with a healthy diet and exercising