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Targeting CD38 improves metabolic fitness and memory in 5xFAD mice via modulation of pathogenic T H 17-mediated immunity To address the potential mechanistic relationship between CD38 and altered T cell immunometabolic functions, we used the 5xFAD transgenic mouse model of AD

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For instance, excluding one study with a large sample size and long follow-up duration reduced heterogeneity from 93% to 78%, yet both levels remained high