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10.1038/NATURE11808 61 MirmiranpourH.MousavizadehM.NoshadS.GhavamiM.EbadiM.GhasemiesfeM.et al (2013)
To do so, we first made recombinant variants (WT and REW) of three recently developed anti-CD20 IgG1 antibodies, with distinct ability to mediate CDC, namely mAb2 (low CDC), mAb1 (intermediate CDC) and mAb9 (high CDC) 42
no LD50 established even at very high doses in rodents No Hormonal Effects: Does not affect testosterone, estrogen, growth hormone, or other hormonal axes Gastric Origin: Derived from a naturally occurring human gastric protein, suggesting good biological compatibility Stability: Unusually stable in gastric acid, supporting oral administration potential Reported Effects: Anecdotal reports of fatigue, nausea in some research subjects TB-500 Safety Profile: (PMID: 20536472) Note: Published safety data is primarily available for Thymosin Beta-4
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