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Side Effects and the Copper Uglies Explained GHK-Cu has a strong safety profile in topical research, but a small subset of users experience a transient phase known as the copper uglies. A 2023 clinical safety review covering 12 studies and 512 participants reported that the most common side effects of topical GHK-Cu were transient and mild

However, the product is not intended for direct veterinary administration and must never be used outside approved laboratory environments

Also, avoid excessive sugar, stop smoking and apply sunscreen daily in the morning to support its brightening action

Mazza MG, De Lorenzo R, Conte C, Poletti S, Vai B, Bollettini I, Melloni EMT, Furlan R, Ciceri F, Rovere-Querini P, Benedetti F (2020) Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors