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This review summarizes the molecular characteristics and antioxidant functions of GPX4, evaluates experimental evidence linking GPX4 and ferroptosis in OA, outlines upstream and downstream molecular mechanisms regulating GPX4, and summarizes therapeutic strategies targeting GPX4, including pharmacological, gene, and combination therapies

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Cagrilintide is most extensively studied in combination with semaglutide (the CagriSema research programme), where the amylin and GLP-1 mechanisms have demonstrated complementary activity in late-stage metabolic trials