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Novel guidelines for testing nanomaterials have been developed within the Malta Initiative since 2017, and the launch of EU-funded projects, including the Horizon 2020-funded NanoHarmony, RiskGONE (Science-based Risk Governance of NanoTechnology), NANORIGO (NANOtechnology RIsk Governance), or Gov4Nano

A minimum fold change 1.5 and maximum false discovery rate (FDR) adjusted p-value (q-value) 0.05 was used to filter proteins that were significantly different between the iPSC, GF-HLCs and SM-HLCs compared to CTR

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