The accelerated approval was based on a Phase II study in which an overall response rate of 73.6% was seen in patients with at least four prior lines of therapy
Intriguingly, GLP1/GIP had limited efficacy in our PCOS model with more severe metabolic complications, i.e., PWA mice fed HFD, suggesting that in the presence of persistently elevated androgen levels, its beneficial effects might be dampened
It is important to note that renal dysfunction can also be affected by the performance of distinct organs, such as the heart, lung, and liver
glutamate reuptake, primarily by astrocytes, is extremely efficient (reviewed in Pittenger, Coric et al., 2008), and therefore increased activity of glutamatergic neurons will not necessarily increase tonic concentrations of glutamate in tissue or in CSF