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While this SAM-mediated allosteric control system is present in many organs, especially the liver, its effect on the methylation cycle in the central nervous system (CNS) may be limited

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203 On re-examination, four of the 17 cases repeatedly tested negative for S100 protein despite various antigen enhancement methods, but they were positive for HMB-45 antigen and contained premelanosomes or melanosome-like structures by electron microscopy