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However, it is unclear if this abundance of thiomethyl derivates is related to a specific susceptibility of this individual to generate NAPQI metabolites, to the pregnancy itself (as sex steroids could be involved in the regulation of CYP2E1 ( 25 )) or to an accumulation of these metabolites in urine over time due to repeated intakes

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Data are synthesized from clinical trials and categorized on a scale from 0 (no effect) to 5 (strong effect)