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In comparison with a high-HDI country like the USA, a marked decrease of 27% in cancer deaths has been observed over the previous two decades, with the number estimated to decrease further (CDC, accessed in 2023) [8]

For instance, 5-HT is a neurotransmitter associated with mood and behavioral inhibition, and elevated levels can lead to increased feelings of fatigue, a phenomenon known as the central fatigue hypothesis. As shown in Figure 1b, 5-HT in the brain is metabolized from tryptophan through tryptophanase (TYH)

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In contrast, bacterial lipopolysaccaride (LPS) is able to trigger thyroiditis in NOD H2h4 mice, by interacting with TLR4 expressed on thyrocytes