Kidney Dis (Basel) (2016) 2(1):207
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Recent studies suggested that UBE3A deficiency alters mitochondrial functioning resulting in oxidative stress [8,9,10,11,12], thus contributing to the deleterious effects on brain functionality [12]
Like other types of animal protein, collagen contains a type of amino acid called hydroxyproline ( Hydroxyproline is converted into oxalate in your body, which may increase levels of oxalate excretion in urine ( In one older study, consuming 30 grams of gelatin derived from collagen increased urinary oxalate excretion by 43% after 24 hours compared with a control group ( Several animal studies also show that consuming high amounts of hydroxyproline could increase oxalate levels in the urine, and therefore, may harm kidney health ( Other test-tube and animal studies suggest that these effects could be amplified in those with primary hyperoxaluria, a genetic disorder that affects oxalate metabolism and increases the risk of recurrent kidney stones ( However, keep in mind that most of these studies used concentrated amounts of hydroxyproline
